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Description
Mouse Anti-Human CD340 Antibody (S-3018)Product Specification Host Mouse Antigen CD340 Synonyms Receptor tyrosine protein kinase erbB 2; Metastatic lymph node gene 19 protein (MLN 19); Proto oncogene Neu; Proto oncogene c ErbB 2; Tyrosine kinase type cell surface receptor HER2; p185erbB2; CD340; HER2; MLN19; NEU; NGL; ERBB2 Location Cytoplasm, Nucleus, Endosome, Cell membrane Accession P04626 Clone Number S 3018 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive
Product Specification
| Host | Mouse |
| Antigen | CD340 |
| Synonyms | Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein (MLN 19); Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; HER2; MLN19; NEU; NGL; ERBB2 |
| Location | Cytoplasm, Nucleus, Endosome, Cell membrane |
| Accession | P04626 |
| Clone Number | S-3018 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | SK-BR-3 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD340, also termed HER2/ErbB2, is a 1,255-amino-acid, 185 kDa glycosylated type-I trans-membrane receptor tyrosine kinase that lacks its own ligand-binding domain yet serves as the dimerization partner of choice for the other epidermal growth-factor receptors; upon hetero-dimerization it triggers potent downstream signaling cascades (MAPK, PI3K–Akt, PLC-γ, STAT) that drive proliferation, survival and microtubule stabilization, is frequently amplified or over-expressed on the surface of breast, ovarian and other epithelial tumours, and is therefore a key therapeutic target for monoclonal antibodies such as trastuzumab and pertuzumab.
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4.2 ★★★★★
Based on 1840 reviews
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Product Reviews
★★★★★ 3
Good But
Format: Kindle
A little disjointed at times, at least to me. This was about Lila (omega woman) and Harrison, Wesley and River (alpha males). The main characters were likeable, as was Lila's friend, Wendy. Lila finally wised up and left the alpha she had been with for a couple of years because he was an a-hole, who treated and used her horribly. She knew some, if not all, of the guys from college if I remember correctly. The guys had been looking for an omega to bond with for some time. When Lila saw Harrison again, the other two guys were out on a date with another omega but Harrison refused to go because he didn't like her. He saw Lila again and knew she was the omega they had been searching for. However, it wasn't easy for them to convince Lila of that because of the way her ex-alpha treated her.
The sex was hot. There was one inconsistency. I could almost swear that when Lila first saw Harrison again, she told her best friend, Wendy, that Harrison was the lead for his pack. Then later on when she's spending time with River, she thinks he is the pack's lead. Maybe I read something incorrectly. All in all, a good story.
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Reviewed in the United States on March 13, 2026
★★★★★ 5
Sweet read
Format: Kindle
A sweet steamy read of an omega who finds her worth and finds the guys that are willing to show her. The story had lovable characters with low angst and a HEA.
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Reviewed in the United States on November 7, 2025
★★★★★ 5
knotty book 1
Format: Kindle
Super enjoyable! What a horrible ex. Was glad to see the back of him, I was hoping I would get to see him suffer a whole lot more.
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Reviewed in the United States on October 5, 2025
★★★★★ 5
Short and sweet
Format: Kindle
Beautifully written, I was worried when it was labelled as a novella at the start, really used to those missing info and jumping forward to complete the story or not having complete character growth, not to worry! Author gave enough time to fall in love (and hate) with everyone, can't wait to read Wendy's story I feel like she will be the badass we all love!
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Reviewed in the United States on August 17, 2025
★★★★★ 3
Likeable characters, but only 75% complete story
Format: Kindle
I really liked the characters introduced, but the author didn’t fully conceptualize everything. We know Lila works long hours, but despite being a college graduate we never learn anything about what she does, where she works, how much she gets paid, etc. For an omega who seemed to be able to support herself, that seemed an unusual oversight. We learn absolutely nothing about what she wants in life, either. Is she just surviving the post-college life struggle or working up to her dream job? Fiona the flamingo had more detail than some of the main characters, but she was 10/10 as good as Wendy for a side character.
— spoilers ahead —-
Separately, some of the plot details were contradictory, or just missing. On one page Lila and Larry were together for 18 months, on another it was 4 years. When did she even move in with him? What did she do while he was gaming? How long were she and Wendy friends for Lila to trust her like that but not know much about her? And why didn’t Lila’s alphas sue Larry to reduce Lila’s debt? Shopping seemed a weird choice pamper her without knowing more about Lila’s debt and plans to reduce it. And her alphas never even ask anything about her job, but she’s The One. Such a frustrating relationship plot hole.
We never even learn anything about the alphas’ families or what they want in life either. I wish the author had written about 30 more pages fleshing out the details and showing how the alphas were just as in love with Lila’s personality as they were with her scent and body. Loved the concept, but I still feel like I read 3/4 of a book.
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Reviewed in the United States on August 29, 2025