Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Mouse Anti-Rat TCR α/β Antibody (S-3806)Product Specification Host Mouse Antigen TCR Location Cell membrane Accession A0A8I6ABG9 Clone Number S 3806 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied Dilution application dilution
Product Specification
| Host | Mouse |
| Antigen | TCR α/β |
| Location | Cell membrane |
| Accession | A0A8I6ABG9 |
| Clone Number | S-3806 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Rt |
Background
TCR α/β protein, the defining heterodimer of the αβ T-cell lineage, is a disulfide-linked transmembrane receptor whose extracellular amino-terminal variable (Vα/Vβ) and constant (Cα/Cβ) Ig-like domains collectively form an antigen-binding groove that recognizes a composite ligand consisting of a peptide non-covalently nestled within the groove of an MHC molecule; this interaction is stabilized by two paired immunoglobulin superfamily domains and anchored to the T-cell membrane via stalk, transmembrane and short cytoplasmic regions that associate with CD3 γε, δε and ζζ signaling subunits, so that ligand-induced conformational change in the αβ heterodimer triggers phosphorylation of ITAMs and initiates the calcium- and kinase-dependent cascade leading to T-cell activation, proliferation and differentiation, thereby making the TCR α/β protein the central sensor that converts extracellular peptide-MHC information into intracellular immune decisions.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy